|
Translational research applies findings from basic science to enhance human health and well-being. In a medical research context, it aims to "translate" findings in fundamental research into medical and nursing practice and meaningful health outcomes. Translational research implements a “bench-to-bedside”, from laboratory experiments through clinical trials to point-of-care patient applications, model, harnessing knowledge from basic sciences to produce new drugs, devices, and treatment options for patients. The end point of translational research is the production of a promising new treatment that can be used with practical applications, that can then be used clinically or are able to be commercialized. As a relatively new research discipline, translational research incorporates aspects of both basic science and clinical research, requiring skills and resources that are not readily available in a basic laboratory or clinical setting. It is for these reasons that translational research is more effective in dedicated university science departments or isolated, dedicated research centres. Since 2009, the field has had a specialized journals, the American Journal of Translational Research and the Translational Research (journal) dedicated to translational research and its findings. Translational research is broken down into five levels, T1 through to T5. ''T1 research'', refers to the “bench-to-bedside” enterprise of translating knowledge from the basic sciences into the development of new treatments; and ''T2 research'' refers to translating the findings from clinical trials into everyday practice.〔 Translational research includes two areas of translation. One is the process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans. The second area of translation concerns research aimed at enhancing the adoption of best practices in the community. Cost-effectiveness of prevention and treatment strategies is also an important part of translational science.〔 == Definitions of Translational Research == As translational research is a relatively new field, an exact definition is difficult to achieve. If ten researchers were asked to define the concept, the ten responses would more than likely differ. Two succinct definitions are listed below. * The National Institutes of Health (NIH) defines translational research as the movement of discoveries in basic research to application at the clinical level. * A paper named 'The Meaning of Translational Research and Why It Matters', by S.H. Woolf, defines translational research as ‘the “bench to bedside” enterprise of harnessing knowledge from basic sciences to products new drugs, devices and treatment options for patients.”〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「translational research」の詳細全文を読む スポンサード リンク
|